JNK cascade [GO_0007254]

A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Tags:

JNK cascade

ID: GO_0007254

Class

A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.

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Classification

Alternative Names

Synonym Scope Reference
MAPK10 cascade narrow synonym add
MAPK9 cascade narrow synonym add
JNK2 cascade narrow synonym add
JNK1 cascade narrow synonym add
JNK3 cascade narrow synonym add
SAPK cascade broad synonym
stress-activated protein kinase cascade broad synonym
MAPK8 cascade exact synonym add
c-Jun N-terminal kinase cascade exact synonym 20811974

References